Publications
(Lab folks in bold)
The dynamics of hematopoiesis over the human lifespan. (biorxiv link)
Li H†, Côté PD, Kuoch M, Ezike J, Frenis K, Afanassiev A, Greenstreet L, Tanaka-Yano M, Tarantino G, Zhang S, Whangbo J, Butty VL, Moiso E, Falchetti M, Lu K, Connelly GG, Morris V, Wang D, Chen AF, Bianchi G, Daley GQ, Garg S, Liu D, Chou ST, Regev A, Lummertz da Rocha E, Schiebinger G, Rowe RG†.Nat Meth. 2024. in press. †co-corresponding
Folate depletion induces erythroid differentiation through perturbation of de novo purine synthesis.
Maynard AG, Pohl NK, Mueller AP, Petrova B, Wong AYL, Wang P, Culhane AJ, Brook JR, Hirsch LM, Hoang N, Kirkland O, Braun T, Ducamp S, Fleming MD, Li H, Kanarek N.Sci Adv. 2024 Feb 2;10(5):eadj9479. doi: 10.1126/sciadv.adj9479. Epub 2024 Jan 31.PMID: 38295180
Wobma H, Kapadia M, Kim HT, Alvarez-Calderon F, Baumeister SHC, Duncan C, Forrest S, Gorfinkel L, Huang J, Lehmann LE, Li H, Schwartz M, Koreth J, Ritz J, Kean LS, Whangbo JS.Blood Adv. 2023 Aug 22;7(16):4647-4657. doi: 10.1182/bloodadvances.2023009729.PMID: 37603347
Connelly GG, Kirkland OO, Bohannon S, Lim DC, Wilson RM, Richards EJ, Tay DM, Jee H, Hellinger RD, Hoang NK, Hao L, Chhabra A, Martin-Alonso C, Tan EKW, Koehler AN, Yaffe MB, London WB, Lee PY, Krammer F, Bohannon RC, Bhatia SN, Sikes HD, Li H.Cell Rep Methods. 2022 Aug 22;2(8):100273. doi: 10.1016/j.crmeth.2022.100273. Epub 2022 Aug 4.PMID: 35942328
Massively parallel pooled screening reveals genomic determinants of nanoparticle delivery.
Boehnke N, Straehla JP, Safford HC, Kocak M, Rees MG, Ronan M, Rosenberg D, Adelmann CH, Chivukula RR, Nabar N, Berger AG, Lamson NG, Cheah JH, Li H, Roth JA, Koehler AN, Hammond PT.Science. 2022 Jul 22;377(6604):eabm5551. doi: 10.1126/science.abm5551. Epub 2022 Jul 22.PMID: 35862544
FACS and immunomagnetic isolation of early erythroid progenitor cells from mouse fetal liver.
Braun TW, Kuoch MK, Khandros E, Li H.STAR Protoc. 2021 Dec 29;3(1):101070. doi: 10.1016/j.xpro.2021.101070. eCollection 2022 Mar 18.PMID: 35024628
Pre-Li Lab
Li H*, Natarajan A*, Ezike J, Barrasa MI, Le Y, Feder ZA, Yang H, Ma C, Markoulaki S, Lodish HF.Dev Cell. 2019 Apr 8;49(1):118-129.e7. doi: 10.1016/j.devcel.2019.01.026. Epub 2019 Feb 28.PMID: 30827895. *co-first
Li H, Benson LA, Henderson LA, Solomon IH, Kennedy AL, Soldatos A, Bielekova B, Murphy J, Davies KJ, Lehmann LE, Lee MA, Alexandrescu S, Degar BA, Gorman MP, Duncan CN.Blood Adv. 2019 Feb 26;3(4):503-507. doi: 10.1182/bloodadvances.2018027417.PMID: 30760465
Pediatric CNS-isolated hemophagocytic lymphohistiocytosis.
Benson LA*, Li H*, Henderson LA, Solomon IH, Soldatos A, Murphy J, Bielekova B, Kennedy AL, Rivkin MJ, Davies KJ, Hsu AP, Holland SM, Gahl WA, Sundel RP, Lehmann LE, Lee MA, Alexandrescu S, Degar BA, Duncan CN, Gorman MP.Neurol Neuroimmunol Neuroinflamm. 2019 Apr 8;6(3):e560. doi: 10.1212/NXI.0000000000000560. eCollection 2019 May.PMID: 31044148. *co-first
Yien YY, Shi J, Chen C, Cheung JTM, Grillo AS, Shrestha R, Li L, Zhang X, Kafina MD, Kingsley PD, King MJ, Ablain J, Li H, Zon LI, Palis J, Burke MD, Bauer DE, Orkin SH, Koehler CM, Phillips JD, Kaplan J, Ward DM, Lodish HF, Paw BH.J Biol Chem. 2018 Dec 21;293(51):19797-19811. doi: 10.1074/jbc.RA118.002742. Epub 2018 Oct 26.PMID: 30366982
Solomon IH, Li H, Benson LA, Henderson LA, Degar BA, Gorman MP, Duncan CN, Lidov HG, Alexandrescu S.J Neuropathol Exp Neurol. 2018 Dec 1;77(12):1079-1084. doi: 10.1093/jnen/nly094.PMID: 30295794
Critical Issues in Diamond-Blackfan Anemia and Prospects for Novel Treatment.
Li H, Lodish HF, Sieff CA.Hematol Oncol Clin North Am. 2018 Aug;32(4):701-712. doi: 10.1016/j.hoc.2018.04.005. Epub 2018 Jun 5.PMID: 30047421
Pishesha N, Bilate AM, Wibowo MC, Huang NJ, Li Z, Deshycka R, Bousbaine D, Li H, Patterson HC, Dougan SK, Maruyama T, Lodish HF, Ploegh HL.Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):3157-3162. doi: 10.1073/pnas.1701746114. Epub 2017 Mar 7.PMID: 28270614
Unclogging sickle cell anaemia.
Li H, Lodish H.Nat Rev Mol Cell Biol. 2017 Apr;18(4):214. doi: 10.1038/nrm.2017.17. Epub 2017 Mar 1.PMID: 28248321
Characteristic peripheral blood smear findings in disorders of cobalamin metabolism.
Li H, Sieff C.Blood. 2016 Nov 24;128(21):2584. doi: 10.1182/blood-2016-08-736991.PMID: 27884837
Efficient CRISPR-Cas9 mediated gene disruption in primary erythroid progenitor cells.
Li H*, Shi J*, Huang NJ, Pishesha N, Natarajan A, Eng JC, Lodish HF.Haematologica. 2016 Jun;101(6):e216-9. doi: 10.3324/haematol.2015.135723. Epub 2016 Mar 11.PMID: 26969085. *co-first
Robust ZFN-mediated genome editing in adult hemophilic mice.
Anguela XM, Sharma R, Doyon Y, Miller JC, Li H, Haurigot V, Rohde ME, Wong SY, Davidson RJ, Zhou S, Gregory PD, Holmes MC, High KA.Blood. 2013 Nov 7;122(19):3283-7. doi: 10.1182/blood-2013-04-497354. Epub 2013 Oct 1.PMID: 24085764
In vivo genome editing restores haemostasis in a mouse model of haemophilia.
Li H, Haurigot V, Doyon Y, Li T, Wong SY, Bhagwat AS, Malani N, Anguela XM, Sharma R, Ivanciu L, Murphy SL, Finn JD, Khazi FR, Zhou S, Paschon DE, Rebar EJ, Bushman FD, Gregory PD, Holmes MC, High KA.Nature. 2011 Jun 26;475(7355):217-21. doi: 10.1038/nature10177.PMID: 21706032
Assessing the potential for AAV vector genotoxicity in a murine model.
Li H, Malani N, Hamilton SR, Schlachterman A, Bussadori G, Edmonson SE, Shah R, Arruda VR, Mingozzi F, Wright JF, Bushman FD, High KA.Blood. 2011 Mar 24;117(12):3311-9. doi: 10.1182/blood-2010-08-302729. Epub 2010 Nov 24.PMID: 21106988
Diverse IgG subclass responses to adeno-associated virus infection and vector administration.
Murphy SL*, Li H*, Mingozzi F, Sabatino DE, Hui DJ, Edmonson SA, High KA.J Med Virol. 2009 Jan;81(1):65-74. doi: 10.1002/jmv.21360.PMID: 19031458. *co-first
Murphy SL, Li H, Zhou S, Schlachterman A, High KA.Mol Ther. 2008 Jan;16(1):138-45. doi: 10.1038/sj.mt.6300334. Epub 2007 Oct 23.PMID: 17955024
Water-mediated association provides an ion pair receptor.
Kotch FW, Sidorov V, Lam YF, Kayser KJ, Li H, Kaucher MS, Davis JT.J Am Chem Soc. 2003 Dec 10;125(49):15140-50. doi: 10.1021/ja0364165.PMID: 14653749